Lupus Nephritis in Pediatric Practice: 20-Year Experience in Care

Purpose of the Study: assessment course and outcomes lupus nephritis in children; determination efficiency use angiotensin-converting enzyme inhibitors for nephritis. Children Characteristics Study Methods. Over a 20-year period, we analyzed data 36 children with systemic erythematosus at ages from 5 to 17 years. Results. In 72.2% cases, kidney damage was noted disease onset, severe, recurrent registered. The nephrotic syndrome has developed 47.2% cases. All patients received comprehensive treatment: corticosteroids, cyclophosphamide, azathioprine, selective immunosuppressants. A study conducted 23 determine enalapril treatment prescribed purpose nephroprotection. It revealed that this drug improves long-term results. There registered twofold decrease recurrence rate, fivefold level daily proteinuria. Five-year survival rate observed 100% patients, 10-year – 91.6%, end-stage renal failure diagnosed 8.4% children. died adult life (mortality is 13.9%). Conclusion. require continuation maintenance therapy. immunosuppressants nephroprotectors contributed survival.